Anti-CCL25 Antibody Prolongs Skin Allograft Survival by Blocking CCR9 Expression and Impairing Splenic T-Cell Function

CXCR3 Expression Directing T Cells into Allograft Survival by Means of Blockade of Peptide Nucleic Acid Antisense Prolongs Skin

Dryocrassin suppresses immunostimulatory function of dendritic cells and prolongs skin allograft survival.

Dendritic cells (DCs) are the major specialized antigen-presenting cells for the development of optimal T-cell immunity. DCs can be used as pharmacological targets to monitor novel biological modifiers for the cure of harmful immune responses, such as transplantation rejection. Dryopteris crassirhizoma Nakai (Aspiadaceae) is used for traditional herbal medicine in the region of East Asia. The r...

Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice

Administration of the monoclonal antibody M7/20, which binds to the murine interleukin-2 (IL) receptor, significantly prolongs cardiac allograft survival in two H-2-incompatible strain combinations of inbred mice. The results support the important role of the IL-2 receptor in the mechanism of graft rejection, and suggest its suitability as a target for immunosuppressive therapy.

Characterization of CCR9 Expression and CCL25/ Thymus-Expressed Chemokine Responsiveness During T Cell Development: CD3CD69 Thymocytes and TCR Thymocytes Preferentially Respond to CCL25

CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion

BACKGROUND Ovarian carcinoma (OvCa) is the most lethal gynecological malignancy among women and its poor prognosis is mainly due to metastasis. Chemokine receptor CCR9 is primarily expressed by a small subset of immune cells and its only natural ligand, CCL25, is largely expressed in the thymus, which involutes with age. Other than the thymus, CCL25 is expressed by the small bowel. Interactions...